Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins
Identifieur interne : 000288 ( France/Analysis ); précédent : 000287; suivant : 000289Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins
Auteurs : Patrick Vermersch ; Delacourte ; France Javoy-Agid [France] ; Jean-Jacques Hauw [France] ; Yves Agid [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 1993-05.
Abstract
In order to elucidate the neurochemical basis of the dementia of Parkinson's disease, we compared samples of cerebral cortex from 24 nondemented parkinsonian patients and parkinsonian patients with various degrees of dementia, with those from patients with Alzheimer's disease and control subjects, using a quantitative Western blot analysis. An anti‐paired helical filaments antibody was used for the immunodetection of the abnormally phosphorylated Tau proteins 55,64, and 69, which are known to be specific and reliable biochemical markers of Alzaheimer‐type neurofibrillary degeneration. The frequency and intensity of immunodetection of the abnormal Tau triplet were higher in the demented parkinsonian subgroups than in the nondemented parkinsonian subgroup in the prefrontal area, temporal cortex, and entorhinal cortex but not in either the occipital or the cingular cortex. A quantification of abnormal Tau triplet by densaitometry showed that unlike the results obtained in Alzheimer patients, the intensity of lesions in the cerebral cortex of the most demented parkinsonian patients was more severe in the prefrontal area versus the temporal area. This study (1) gives biochemical evidence for Alzheimer‐type changes in the cortex of demented parkinsonian patients and (2) suggests that lesions of the prefrontal cortex may significantly contribute to the occurrence of cognitive changes at least in some patients with Parkinson's disease.
Url:
DOI: 10.1002/ana.410330506
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 001180
- to stream Main, to step Curation: 000F81
- to stream Main, to step Exploration: 002558
- to stream France, to step Extraction: 000288
Links to Exploration step
ISTEX:92C19D9A1CC945E3A79C5D9E989ECAD981A32482Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins</title><author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name></author><author><name sortKey="Delacourte" sort="Delacourte" uniqKey="Delacourte" last="Delacourte">Delacourte</name></author><author><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name></author><author><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:92C19D9A1CC945E3A79C5D9E989ECAD981A32482</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1002/ana.410330506</idno><idno type="url">https://api.istex.fr/document/92C19D9A1CC945E3A79C5D9E989ECAD981A32482/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001180</idno><idno type="wicri:Area/Main/Curation">000F81</idno><idno type="wicri:Area/Main/Exploration">002558</idno><idno type="wicri:Area/France/Extraction">000288</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins</title><author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name><affiliation><wicri:noCountry code="subField">Lille</wicri:noCountry></affiliation></author><author><name sortKey="Delacourte" sort="Delacourte" uniqKey="Delacourte" last="Delacourte">Delacourte</name><affiliation><wicri:noCountry code="subField">Lille</wicri:noCountry></affiliation></author><author><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Unité INSERM 289</wicri:orgArea></affiliation></author><author><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neuropathologie Raymond Escourolle, Hǒpital de La Salpětrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Unité INSERM 289</wicri:orgArea><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993-05">1993-05</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="445">445</biblScope><biblScope unit="page" to="450">450</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">92C19D9A1CC945E3A79C5D9E989ECAD981A32482</idno><idno type="DOI">10.1002/ana.410330506</idno><idno type="ArticleID">ANA410330506</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to elucidate the neurochemical basis of the dementia of Parkinson's disease, we compared samples of cerebral cortex from 24 nondemented parkinsonian patients and parkinsonian patients with various degrees of dementia, with those from patients with Alzheimer's disease and control subjects, using a quantitative Western blot analysis. An anti‐paired helical filaments antibody was used for the immunodetection of the abnormally phosphorylated Tau proteins 55,64, and 69, which are known to be specific and reliable biochemical markers of Alzaheimer‐type neurofibrillary degeneration. The frequency and intensity of immunodetection of the abnormal Tau triplet were higher in the demented parkinsonian subgroups than in the nondemented parkinsonian subgroup in the prefrontal area, temporal cortex, and entorhinal cortex but not in either the occipital or the cingular cortex. A quantification of abnormal Tau triplet by densaitometry showed that unlike the results obtained in Alzheimer patients, the intensity of lesions in the cerebral cortex of the most demented parkinsonian patients was more severe in the prefrontal area versus the temporal area. This study (1) gives biochemical evidence for Alzheimer‐type changes in the cortex of demented parkinsonian patients and (2) suggests that lesions of the prefrontal cortex may significantly contribute to the occurrence of cognitive changes at least in some patients with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Delacourte" sort="Delacourte" uniqKey="Delacourte" last="Delacourte">Delacourte</name><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name></region><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000288 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000288 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:92C19D9A1CC945E3A79C5D9E989ECAD981A32482
|texte= Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins
}}
| This area was generated with Dilib version V0.6.23. |  |